Localizing seizure onset zone by a cortico-cortical evoked potentials-based machine learning approach in focal epilepsy.
Clin Neurophysiol
; 158: 103-113, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38218076
ABSTRACT
OBJECTIVE:
We aimed to develop a new approach for identifying the localization of the seizure onset zone (SOZ) based on corticocortical evoked potentials (CCEPs) and to compare the connectivity patterns in patients with different clinical phenotypes.METHODS:
Fifty patients who underwent stereoelectroencephalography and CCEP procedures were included. Logistic regression was used in the model, and six CCEP metrics were input as features root mean square of the first peak (N1RMS) and second peak (N2RMS), peak latency, onset latency, width duration, and area.RESULTS:
The area under the curve (AUC) for localizing the SOZ ranged from 0.88 to 0.93. The N1RMS values in the hippocampus sclerosis (HS) group were greater than that of the focal cortical dysplasia (FCD) IIa group (p < 0.001), independent of the distance between the recorded and stimulated sites. The sensitivity of localization was higher in the seizure-free group than in the non-seizure-free group (p = 0.036).CONCLUSIONS:
This new method can be used to predict the SOZ localization in various focal epilepsy phenotypes.SIGNIFICANCE:
This study proposed a machine-learning approach for localizing the SOZ. Moreover, we examined how clinical phenotypes impact large-scale abnormality of the epileptogenic networks.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Epilepsies, Partial
/
Electroencephalography
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Clin Neurophysiol
Year:
2024
Document type:
Article