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A bis-quinoline ruthenium(II) arene complex with submicromolar cytotoxicity in castration-resistant prostate cancer cells.
Khan, Tanveer A; Bhar, Kishalay; Samanta, Rohit; Bhatt, Surabhi; Singh, Mamta; Rani, Reshma; Kumar, Vinit; Sharma, Anuj K.
Affiliation
  • Khan TA; Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India. anuj.sharma@curaj.ac.in.
  • Bhar K; Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India. anuj.sharma@curaj.ac.in.
  • Samanta R; Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India. anuj.sharma@curaj.ac.in.
  • Bhatt S; Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India. anuj.sharma@curaj.ac.in.
  • Singh M; Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh 201313, India.
  • Rani R; Jubilant Biosys, Greater Noida, UP 201310, India.
  • Kumar V; Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh 201313, India.
  • Sharma AK; Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India. anuj.sharma@curaj.ac.in.
Chem Commun (Camb) ; 60(12): 1579-1582, 2024 Feb 06.
Article in En | MEDLINE | ID: mdl-38224119
ABSTRACT
A new Ru(II) arene chlorido organometallic complex [(η6-p-cymene)(L)RuCl]PF6 (named as pCYRuL) using 2-bis(quinolin-2-ylmethylene) hydrazine (L) was developed that exhibits potent anticancer activity against castration-resistant prostate cancer (CRPC) (IC50 = 0.71 µM), and it is 45 times more effective than the standard drug cisplatin (IC50 = 31.3 µM) in a castration-resistant human prostatic adenocarcinoma cell line (PC-3) but non-toxic in normal human kidney cells (HK2) as well as normal breast cells (MCF10A) and found that pCYRuL exerted anticancer activity via apoptosis induction and cell cycle arrest in the G2/M phase of PC-3 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Ruthenium / Coordination Complexes / Prostatic Neoplasms, Castration-Resistant / Antineoplastic Agents Limits: Humans / Male Language: En Journal: Chem Commun (Camb) Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Ruthenium / Coordination Complexes / Prostatic Neoplasms, Castration-Resistant / Antineoplastic Agents Limits: Humans / Male Language: En Journal: Chem Commun (Camb) Year: 2024 Document type: Article