Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice.
J Pharmacol Sci
; 154(2): 72-76, 2024 Feb.
Article
in En
| MEDLINE
| ID: mdl-38246730
ABSTRACT
Alternatives to ketamine without psychotomimetic properties for the treatment of depression have attracted much attention. Here, we examined the anti-despair and anti-anhedonia effects of the ketamine metabolites (S)-norketamine ((S)-NK), (R)-NK, (2S,6S)-hydroxynorketamine, and (2R,6R)-hydroxynorketamine in a mouse model of depression induced by social isolation. All ketamine metabolites examined had acute (30 min after administration) anti-despair-like effects in the forced swim test, but only (S)-NK showed a long-lasting (1 week) effect. Additionally, only (S)-NK improved reduced motivation both 30 min and 24 h after injection in the female encounter test. These results suggest that (S)-NK has potent and long-lasting antidepressant-like effects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ketamine
Aspects:
Determinantes_sociais_saude
Limits:
Animals
Language:
En
Journal:
J Pharmacol Sci
Year:
2024
Document type:
Article