In-vitro and In Silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare.
Antiinflamm Antiallergy Agents Med Chem
; 23(1): 14-20, 2024.
Article
in En
| MEDLINE
| ID: mdl-38258776
ABSTRACT
BACKGROUND:
Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties.OBJECTIVES:
This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Additionally, we seek to quantify and compare the phytochemical content of two distinct extracts Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ).METHODS:
We quantified the phytochemical contents of BGHE and BGAQ and evaluated their anti-inflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts.RESULTS:
Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation compared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts.CONCLUSION:
Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including anti-inflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hordeum
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Plant Extracts
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Apigenin
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Glucosides
/
Anti-Inflammatory Agents
Limits:
Humans
Language:
En
Journal:
Anti-inflammatory and anti-allergy agents in medicinal chemistry (Online)
/
Antiinflamm Antiallergy Agents Med Chem
Year:
2024
Document type:
Article