Your browser doesn't support javascript.
loading
Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants.
Cervera, Soledad Belén; Saeed, Sahar; Luu, Thuy Mai; Gorgos, Andrea; Beltempo, Marc; Claveau, Martine; Basso, Olga; Lapointe, Anie; Tremblay, Sophie; Altit, Gabriel.
Affiliation
  • Cervera SB; Division of Neonatology, Department of Paediatrics, Sainte-Justine University Health Center, Montréal, QC, Canada.
  • Saeed S; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
  • Luu TM; Neonatal Follow-Up, Department of Paediatrics, Université de Montréal, Montreal, QC, Canada.
  • Gorgos A; Neonatal Follow-Up, Department of Pediatrics, McGill University, Montreal, QC, Canada.
  • Beltempo M; Division of Neonatology, Department of Pediatrics, McGill University, Montreal, QC, Canada.
  • Claveau M; Division of Neonatology, Department of Pediatrics, McGill University, Montreal, QC, Canada.
  • Basso O; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
  • Lapointe A; Division of Neonatology, Department of Paediatrics, Sainte-Justine University Health Center, Montréal, QC, Canada.
  • Tremblay S; Division of Neonatology, Department of Paediatrics, Sainte-Justine University Health Center, Montréal, QC, Canada.
  • Altit G; Division of Neonatology, Department of Paediatrics, Sainte-Justine University Health Center, Montréal, QC, Canada. gabriel.altit@mcgill.ca.
J Perinatol ; 44(3): 388-395, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38278962
ABSTRACT

OBJECTIVE:

Assess if unit-level PDA management correlates with neurodevelopmental impairment (NDI) at 18-24 months corrected postnatal age (CPA) in extremely preterm infants. STUDY

DESIGN:

Retrospective analysis of infants born at <29 weeks (2014-2017) across two units having distinct PDA strategies. Site 1 utilized an echocardiography-based treatment strategy aiming for accelerated closure (control). Site 2 followed a conservative approach. PRIMARY ENDPOINT NDI, characterized by cerebral palsy, any Bayley-III composite score <85, sensorineural/mixed hearing loss, or at least unilateral visual impairment.

RESULTS:

377 infants were evaluated. PDA treatment rates remained unchanged in Site 1 but eventually reached 0% in Site 2. Comparable rates of any/significant NDI were seen across both sites (any NDI 38% vs 36%; significant NDI 13% vs 10% for Site 1 and 2, respectively). After adjustments, NDI rates remained similar.

CONCLUSION:

PDA management strategies in extremely preterm newborns showed no significant impact on neurodevelopment outcomes at 18-24 months CPA.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Persistent Fetal Circulation Syndrome / Ductus Arteriosus, Patent Type of study: Risk_factors_studies Limits: Humans / Infant / Newborn Language: En Journal: J Perinatol Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Persistent Fetal Circulation Syndrome / Ductus Arteriosus, Patent Type of study: Risk_factors_studies Limits: Humans / Infant / Newborn Language: En Journal: J Perinatol Year: 2024 Document type: Article