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Pterostilbene upregulates MICA/B via the PI3K/AKT signaling pathway to enhance the capability of natural killer cells to kill cervical cancer cells.
Li, Zuoping; Zhang, Jiaru; You, Shiwan; Zhang, Jing; Zhang, Yuling; Akram, Zubair; Sun, Shiguo.
Affiliation
  • Li Z; Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education, Shihezi University College of Pharmacy, Shihezi, 832003, Xinjiang, China; Shihezi University College of Chemistry and Chemical Engineering, Shihezi, 832002, Xinjiang, China. Electronic address: 1667754715@qq.com.
  • Zhang J; Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education, Shihezi University College of Pharmacy, Shihezi, 832003, Xinjiang, China. Electronic address: 1369477990@qq.com.
  • You S; Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education, Shihezi University College of Pharmacy, Shihezi, 832003, Xinjiang, China. Electronic address: 1974331080@qq.com.
  • Zhang J; Shihezi University College of Chemistry and Chemical Engineering, Shihezi, 832002, Xinjiang, China. Electronic address: 1693732765@qq.com.
  • Zhang Y; Shihezi University College of Chemistry and Chemical Engineering, Shihezi, 832002, Xinjiang, China. Electronic address: LynnLynn@88.com.
  • Akram Z; Shihezi University College of Chemistry and Chemical Engineering, Shihezi, 832002, Xinjiang, China. Electronic address: zubair.a.sidhu@gmail.com.
  • Sun S; Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education, Shihezi University College of Pharmacy, Shihezi, 832003, Xinjiang, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling,
Exp Cell Res ; 435(2): 113933, 2024 Feb 15.
Article in En | MEDLINE | ID: mdl-38296018
ABSTRACT
Natural killer (NK) cells are triggered by the innate immune response in the tumor microenvironment. The extensive set of stimulating and inhibiting receptors mediates the target recognition of NK cells, and controls the strength of the effector reaction countering specific targeted cells. Yet, lacking major MHC (histocompatibility complex) MICA/B class I chain-related proteins on the membrane of tumor cells results in the failure of NK cell recognition and ability to resist NK cell destruction. Searching databases and molecular docking suggested that in cervical cancer, pterostilbene (3,5-dimethoxy-40-hydroxystilbene; PTS) in Vaccinium corymbosum extract could constrain PI3K/AKT signaling and improving the MICA/B expression. In flow cytometry, MTT assay, viability/cytotoxicity assay, and colony development assays, PTS reduced the development of cervical cancer cells and increased apoptosis. The quantitative real-time PCR (qRT-PCR) and a Western blot indicate that PTS controlled the cytolytic action of NK cells in tumor cells via increasing the MICA/B expression, thus modifying the anti-tumor immune response in cervical cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Proto-Oncogene Proteins c-akt Limits: Female / Humans Language: En Journal: Exp Cell Res Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Proto-Oncogene Proteins c-akt Limits: Female / Humans Language: En Journal: Exp Cell Res Year: 2024 Document type: Article