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The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study.
Gao, Xusheng; Li, Tongxia; Han, Wenge; Xiong, Yu; Xu, Shiyang; Ma, Hongbao; Wang, Qing; Zhang, Qiuxia; Yang, Guofeng; Xie, Dan; Jiang, Peipei; Wu, Hailiang; Lin, Mei; Liu, Min; Ni, Mingde; Wang, Decui; Li, Ying; Jiao, Lunxian; Ding, Caihong; Zhang, Zhongfa.
Affiliation
  • Gao X; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Li T; Department of Tuberculosis, Qingdao Chest Hospital, Qingdao, Shandong, China.
  • Han W; Department of Tuberculosis, Weifang Second People's Hospital, Weifang, Shandong, China.
  • Xiong Y; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Xu S; Department of Tuberculosis, Dezhou Second People's Hospital, Dezhou, Shandong, China.
  • Ma H; Department of Tuberculosis, Yantai Pulmonary Hospital, Yantai, Shandong, China.
  • Wang Q; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Zhang Q; Department of Internal Medicine, Zaozhuang Tumor Hospital, Zaozhuang, Shandong, China.
  • Yang G; Department of Tuberculosis, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, China.
  • Xie D; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Jiang P; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Wu H; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Lin M; Department of Tuberculosis, Qingdao Chest Hospital, Qingdao, Shandong, China.
  • Liu M; Department of Respiratory Medicine, Tai'an Tumor Prevention and Treatment Hospital, Tai'an, Shandong, China.
  • Ni M; Department of Tuberculosis, Linyi People's Hospital, Linyi, Shandong, China.
  • Wang D; Department of Tuberculosis, Binzhou Central Hospital, Binzhou, Shandong, China.
  • Li Y; Department of Internal Medicine, Zibo First Hospital, Zibo, Shandong, China.
  • Jiao L; Third Department of Respiratory Medicine, Yantai Beihai Hospital, Yantai, Shandong, China.
  • Ding C; Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
  • Zhang Z; Respiratory Center, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, China.
Front Public Health ; 12: 1322426, 2024.
Article in En | MEDLINE | ID: mdl-38304182
ABSTRACT

Objective:

To investigate the positivity rates and drug resistance characteristics of Mycobacterium tuberculosis (MTB) among suspected tuberculosis (TB) patients in Shandong Province, the second-largest population province in China.

Methods:

A prospective, multi-center study was conducted from April 2022 to June 2023. Pathogen and drug resistance were identified using nucleotide matrix-assisted laser desorption ionization time-of-flight mass spectrometry (nucleotide MALDI-TOF MS).

Results:

Of 940 suspected TB patients included in this study, 552 cases were found to be infected with MTB giving an overall positivity rate of 58.72%. Total of 346 cases were resistant to arbitrary anti-TB drug (62.68%), with Zibo (76.47%), Liaocheng and Weihai (both 69.23%) ranking top three and TB treatment history might be a related factor. Monoresistance was the most common pattern (33.53%), with isoniazid the highest at 12.43%, followed by rifampicin at 9.54%. Further analysis of gene mutations conferring resistance revealed diverse types with high heteroresistance rate found in multiple anti-TB drugs.

Conclusion:

A relatively high rate of MTB positivity and drug resistance was found in Shandong Province during and after the COVID-19 pandemic, indicating the need for strengthening rapid identification of species and drug resistance among suspected TB patients to guide better medication and minimize the occurrence of drug resistance.
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Tuberculosis / Mycobacterium tuberculosis Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Front Public Health Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Tuberculosis / Mycobacterium tuberculosis Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Front Public Health Year: 2024 Document type: Article