SARS-Cov-2 small viral RNA suppresses gene expression via complementary binding to mRNA 3' UTR.
MicroPubl Biol
; 20242024.
Article
in En
| MEDLINE
| ID: mdl-38312351
ABSTRACT
SARS-CoV-2 (SC2) has been intensely studied since its emergence. However, the mechanisms of host immune dysregulation triggered by SC2 remain poorly understood. That said, it is well established that many prominent viral families encode microRNAs (miRNAs) or related small viral RNAs (svRNAs) capable of regulating human genes involved in immune function. Importantly, recent reports have shown that SC2 encodes its own svRNAs. In this study, we have identified 12 svRNAs expressed during SC2 infection and show that one of these svRNAs can regulate target gene expression via complementary binding to mRNA 3' untranslated regions (3'UTRs) much like human microRNAs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
MicroPubl Biol
Year:
2024
Document type:
Article