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Method Comparison of Erythrocyte Sedimentation Rate Automated Systems, the VES-MATIC 5 (DIESSE) and Test 1 (ALIFAX), with the Reference Method in Routine Practice.
Cennamo, Michele; Giuliano, Loredana; Arrigoni, Gloria; Fardone, Valentina; Russo, Roberta; De Tomasi, Luca Maria; Bertani, Fabio; Cammarota, Gaetano; Brunetti, Giovanni; Del Vecchio, Lucia; Partenope, Michelarcangelo.
Affiliation
  • Cennamo M; Department of Translational Medical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
  • Giuliano L; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Arrigoni G; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Fardone V; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Russo R; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • De Tomasi LM; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Bertani F; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Cammarota G; Clinical Pathology and Microbiology Unit, Laboratory Analysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
  • Brunetti G; Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
  • Del Vecchio L; Department of Diagnostics and Public Health, Section of Clinical Biochemistry, University of Verona, 37134 Verona, Italy.
  • Partenope M; Department of Nephrology and Dialysis, ASST Lariana, Hospital Sant'Anna, 22100 Como, Italy.
J Clin Med ; 13(3)2024 Feb 01.
Article in En | MEDLINE | ID: mdl-38337540
ABSTRACT

Background:

The erythrocyte sedimentation rate (ESR) is a routine and aspecific test that is still widely used. The reference-manual method for ESR determination is the Westergren method. The VES-MATIC 5 is a novel, fully automated, and closed system based on a modified Westergren method. This study conceived the aim of comparing two ESR analytical analysers, Test 1 and the VES-MATIC 5, with the reference method in routine practice.

Methods:

This study included 264 randomly analysed samples. A comparison between the two methods and Westergren was performed, and they were evaluated for inter-run and intra-run precision. In addition, we investigated possible interferences and different sensitivities to conventional analytes.

Results:

The comparison of methods by Passing-Bablok analysis provided a good agreement for both systems, with a better correlation for VES-MATIC 5 (p = 0.96) than Test 1 (p = 0.93), and sensitivity studies did not show any significant influence.

Conclusions:

The VES-MATIC 5 analyser demonstrated excellent comparability with the reference method, and it had better performance than Test 1. It can be employed in routine practice, bringing advantages such as a reduction in the probability of human error compared to the manual method, as well as an increase in operator safety and environmental protection.
Key words

Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Type of study: Guideline Language: En Journal: J Clin Med Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Type of study: Guideline Language: En Journal: J Clin Med Year: 2024 Document type: Article