Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance.
NPJ Precis Oncol
; 8(1): 31, 2024 Feb 10.
Article
in En
| MEDLINE
| ID: mdl-38341519
ABSTRACT
Tumor drug resistance emerges from the interaction of two critical factors tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME. M2-like TAMs are essential in facilitating tumor metastasis as well as augmenting the drug resistance of tumors. This review encapsulates the mechanisms that M2-like TAMs use to promote tumor drug resistance. We also describe the emerging therapeutic strategies that are currently targeting M2-like TAMs in combination with other antitumor drugs, with some still undergoing clinical trial evaluation. Furthermore, we summarize and analyze various existing approaches for developing novel drugs that target M2-like TAMs to overcome tumor resistance, highlighting how targeting M2-like TAMs can effectively stop tumor growth, metastasis, and overcome tumor drug resistance.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Journal:
NPJ Precis Oncol
Year:
2024
Document type:
Article