Anaplastic lymphoma kinase-positive histiocytosis with multisystem involvement: A case report.
Pediatr Dermatol
; 41(3): 551-553, 2024.
Article
in En
| MEDLINE
| ID: mdl-38346136
ABSTRACT
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a rare disease that usually occurs in infants and young children and is characterized by ALK-positive histiocytes infiltrating organs. We present a case of multisystem involvement of ALK-positive histiocytosis in a female infant with skin nodules as the initial presentation. Despite multiorgan involvement, most tumors had spontaneously regressed, and all bones were partially healed after 40 months of regular follow-up without treatment. However, gait abnormalities persisted, indicating that early treatment may have greater impact in maintaining a child's quality of life when the disease involves the brain or the critical period of bone development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histiocytosis
/
Anaplastic Lymphoma Kinase
Aspects:
Patient_preference
Limits:
Female
/
Humans
/
Infant
Language:
En
Journal:
Pediatr Dermatol
Year:
2024
Document type:
Article