In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide.
Probiotics Antimicrob Proteins
; 2024 Feb 19.
Article
in En
| MEDLINE
| ID: mdl-38372937
ABSTRACT
The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Probiotics Antimicrob Proteins
Year:
2024
Document type:
Article