Your browser doesn't support javascript.
loading
Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex.
Glasgow, Stephen D; Fisher, Teddy A J; Wong, Edwin W; Lançon, Kevin; Feighan, Kira M; Beamish, Ian V; Gibon, Julien; Séguéla, Philippe; Ruthazer, Edward S; Kennedy, Timothy E.
Affiliation
  • Glasgow SD; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Fisher TAJ; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Wong EW; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Lançon K; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Feighan KM; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Beamish IV; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Gibon J; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Séguéla P; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada.
  • Ruthazer ES; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada. Electronic address: edward.ruthazer@mcgill.ca.
  • Kennedy TE; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada. Electronic address: timothy.kennedy@mcgill.ca.
Cell Rep ; 43(2): 113812, 2024 Feb 27.
Article in En | MEDLINE | ID: mdl-38377003
ABSTRACT
The ability of the mammalian brain to maintain spatial representations of external or internal information for short periods of time has been associated with sustained neuronal spiking and reverberatory neural network activity in the medial entorhinal cortex. Here, we show that conditional genetic deletion of netrin-1 or the netrin receptor deleted-in-colorectal cancer (DCC) from forebrain excitatory neurons leads to deficits in short-term spatial memory. We then demonstrate that conditional deletion of either netrin-1 or DCC inhibits cholinergic persistent firing and show that cholinergic activation of muscarinic receptors expressed by entorhinal cortical neurons promotes persistent firing by recruiting DCC to the plasma membrane. Together, these findings indicate that normal short-term spatial memory function requires the synergistic actions of acetylcholine and netrin-1.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholine / Entorhinal Cortex Limits: Animals Language: En Journal: Cell Rep Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholine / Entorhinal Cortex Limits: Animals Language: En Journal: Cell Rep Year: 2024 Document type: Article