1-Kestose Blocks UVB-Induced Skin Inflammation and Promotes Type I Procollagen Synthesis via Regulating MAPK/AP-1, NF-κB and TGF-ß/Smad Pathway.
J Microbiol Biotechnol
; 34(4): 911-919, 2024 Apr 28.
Article
in En
| MEDLINE
| ID: mdl-38379292
ABSTRACT
Solar UVB irradiation cause skin photoaging by inducing the high expression of matrix metalloproteinase (MMPs) to inhibit the expression of Type1 procollagen synthesis. 1-Kestose, a natural trisaccharide, has been indicated to show a cytoprotective role in UVB radiation-induced-HaCaT cells. However, few studies have confirmed the anti-aging effects. In the present study, we evaluated the anti-photoaging and pathological mechanism of 1-kestose using Human keratinocytes (HaCaT) cells. The results found that 1-kestose pretreatment remarkably reduced UVB-generated reactive oxygen species (ROS) accumulation in HaCaT cells. 1-Kestose suppressed UVB radiation-induced MMPs expressions by blocking MAPK/AP-1 and NF-κB p65 translocation. 1-Kestose pretreatment increased Type 1 procollagen gene expression levels by activating TGF-ß/Smad signaling pathway. Taken together, our results demonstrate that 1-kestose may serve as a potent natural trisaccharide for inflammation and photoaging prevention.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trisaccharides
/
Ultraviolet Rays
/
Signal Transduction
/
Skin Aging
/
Collagen Type I
Limits:
Humans
Language:
En
Journal:
J Microbiol Biotechnol
Year:
2024
Document type:
Article