Your browser doesn't support javascript.
loading
Adjuvanted nanoliposomes displaying six hemagglutinins and neuraminidases as an influenza virus vaccine.
Sia, Zachary R; Roy, Jayishnu; Huang, Wei-Chiao; Song, Yiting; Zhou, Shiqi; Luo, Yuan; Li, Qinzhe; Arpin, Dominic; Kutscher, Hilliard L; Ortega, Joaquin; Davidson, Bruce A; Lovell, Jonathan F.
Affiliation
  • Sia ZR; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Roy J; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Huang WC; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA; POP Biotechnologies, Buffalo, NY 14228, USA.
  • Song Y; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Zhou S; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Luo Y; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Li Q; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.
  • Arpin D; Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.
  • Kutscher HL; POP Biotechnologies, Buffalo, NY 14228, USA; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.
  • Ortega J; Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canada.
  • Davidson BA; Department of Anesthesiology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA. Electronic address: bdavidso@buffalo.edu.
  • Lovell JF; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA. Electronic address: jflovell@buffalo.edu.
Cell Rep Med ; 5(3): 101433, 2024 Mar 19.
Article in En | MEDLINE | ID: mdl-38401547
ABSTRACT
Inclusion of defined quantities of the two major surface proteins of influenza virus, hemagglutinin (HA) and neuraminidase (NA), could benefit seasonal influenza vaccines. Recombinant HA and NA multimeric proteins derived from three influenza serotypes, H1N1, H3N2, and type B, are surface displayed on nanoliposomes co-loaded with immunostimulatory adjuvants, generating "hexaplex" particles that are used to immunize mice. Protective immune responses to hexaplex liposomes involve functional antibody elicitation against each included antigen, comparable to vaccination with monovalent antigen particles. When compared to contemporary recombinant or adjuvanted influenza virus vaccines, hexaplex liposomes perform favorably in many areas, including antibody production, T cell activation, protection from lethal virus challenge, and protection following passive sera transfer. Based on these results, hexaplex liposomes warrant further investigation as an adjuvanted recombinant influenza vaccine formulation.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Influenza Vaccines / Orthomyxoviridae Infections / Influenza, Human / Influenza A Virus, H1N1 Subtype Limits: Animals / Humans Language: En Journal: Cell Rep Med Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Influenza Vaccines / Orthomyxoviridae Infections / Influenza, Human / Influenza A Virus, H1N1 Subtype Limits: Animals / Humans Language: En Journal: Cell Rep Med Year: 2024 Document type: Article