Chemical Constituents of Ajuga Lupulina and their Anti-Ferroptosis Activity.
Chem Biodivers
; 21(4): e202400244, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38426640
ABSTRACT
Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were revealed by analysing spectroscopic data (MS, NMR), and experimental and calculated ECD spectra was used to deduce the absolute configuration. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, the abietane-type diterpenoids (7-11) significantly inhibited ferroptosis with EC50 values of 0.83â
µM, 2.05â
µM, 0.96â
µM, 1.47â
µM, and 1.19â
µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ajuga
/
Ferroptosis
Limits:
Animals
Language:
En
Journal:
Chem Biodivers
Year:
2024
Document type:
Article