[The 504th case: Multiple lymph node enlargement, renal insufficiency, blindness, and white matter lesions of the brain].
Zhonghua Nei Ke Za Zhi
; 63(3): 316-320, 2024 Mar 01.
Article
in Zh
| MEDLINE
| ID: mdl-38448196
ABSTRACT
A 65-year-old male patient was admitted for recurrent lymph node enlargement for 5 years and elevated creatinine for 6 months. This patient was diagnosed with angioimmunoblastic T-cell lymphoma 5 years ago and underwent multiple lines of anti-tumor therapy, including cytotoxic chemotherapy; epigenetic modifying drugs such as chidamide and azacitidine; the immunomodulator lenalidomide; and targeted therapy such as rituximab, a CD20-targeting antibody, and brentuximab vedotin, which targets CD30. Although the tumor was considered stable, multiple virus activation (including BK virus, JC virus, and cytomegalovirus) accompanied by the corresponding organ damage (polyomavirus nephropathy, cytomegalovirus retinitis, and progressive multifocal leukoencephalopathy) occurred during anti-tumor treatment. Anti-tumor therapy was suspended and ganciclovir was used. The serum viral load decreased and organ functions were stabilized. The purpose of this report was to raise clinicians' awareness of opportunistic virus reactivation during anti-tumor treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Renal Insufficiency
/
White Matter
/
Lymphadenopathy
Limits:
Aged
/
Humans
/
Male
Language:
Zh
Journal:
Chung-Hua Nei Ko Tsa Chih (Chinese Journal of Internal Medicine)
/
Zhonghua Nei Ke Za Zhi
Year:
2024
Document type:
Article