Monogenic Kidney Diseases in Kidney Transplantation.
Kidney Int Rep
; 9(3): 549-568, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38481491
ABSTRACT
Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy. KT requires specific considerations depending on the nature of the genetic disorder, the potential oncological risk, the risk of recurrence in the graft, the possibility of specific complications of immunosuppression, and the issue of living donation. The availability of genetic testing should play an increasing role in the evaluation of patients or related living donor candidates before transplantation, relevant for the pretransplantation and posttransplantation management.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Kidney Int Rep
Year:
2024
Document type:
Article