High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries.
SLAS Discov
; 29(3): 100149, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38492994
ABSTRACT
The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitative solubility values of the studied compounds but can be used as a primary solubility assessment of large chemical libraries, to guide hit prioritization after High Throughput Screening (HTS) campaigns.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Solubility
/
Water
/
Small Molecule Libraries
/
High-Throughput Screening Assays
Language:
En
Journal:
SLAS Discov
Year:
2024
Document type:
Article