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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries.
Brea, Jose; Varela, Maria J; Daudey, Geert A; Loza, Maria I.
Affiliation
  • Brea J; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Health Research Institute of Santiago de Compos
  • Varela MJ; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
  • Daudey GA; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
  • Loza MI; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), School of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Health Research Institute of Santiago de Compos
SLAS Discov ; 29(3): 100149, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38492994
ABSTRACT
The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitative solubility values of the studied compounds but can be used as a primary solubility assessment of large chemical libraries, to guide hit prioritization after High Throughput Screening (HTS) campaigns.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Solubility / Water / Small Molecule Libraries / High-Throughput Screening Assays Language: En Journal: SLAS Discov Year: 2024 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Solubility / Water / Small Molecule Libraries / High-Throughput Screening Assays Language: En Journal: SLAS Discov Year: 2024 Document type: Article