Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Nat Metab
; 6(4): 651-658, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38499765
ABSTRACT
Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylalanine
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Diabetes Mellitus, Type 2
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Metformin
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nat Metab
Year:
2024
Document type:
Article