Progress on synthesis and structure-activity relationships of lamellarins over the past decade.
Eur J Med Chem
; 269: 116294, 2024 Apr 05.
Article
in En
| MEDLINE
| ID: mdl-38508119
ABSTRACT
Lamellarins are polyaromatic alkaloids isolated from marine organisms, including mollusks, tunicates, and sponges. Currently, over 60 structurally distinct natural lamellarins have been reported, and most of them exhibit promising biological activities, such as topoisomerase inhibition, mitochondrial function inhibition, multidrug resistance reversing, and anti-HIV activity. There has also been a significant progress on the synthetic study of lamellarins which has been regularly updated by numerous medicinal chemists as well. This review provides a detailed summary of the synthesis, pharmacology, and structural modification of lamellarins over the past decades.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urochordata
/
Biological Products
/
Alkaloids
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2024
Document type:
Article