Physiologic disruption and metabolic reprogramming in infection and sepsis.
Cell Metab
; 36(5): 927-946, 2024 May 07.
Article
in En
| MEDLINE
| ID: mdl-38513649
ABSTRACT
Effective responses against severe systemic infection require coordination between two complementary defense strategies that minimize the negative impact of infection on the host resistance, aimed at pathogen elimination, and disease tolerance, which limits tissue damage and preserves organ function. Resistance and disease tolerance mostly rely on divergent metabolic programs that may not operate simultaneously in time and space. Due to evolutionary reasons, the host initially prioritizes the elimination of the pathogen, leading to dominant resistance mechanisms at the potential expense of disease tolerance, which can contribute to organ failure. Here, we summarize our current understanding of the role of physiological perturbations resulting from infection in immune response dynamics and the metabolic program requirements associated with resistance and disease tolerance mechanisms. We then discuss how insight into the interplay of these mechanisms could inform future research aimed at improving sepsis outcomes and the potential for therapeutic interventions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sepsis
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Metab
Year:
2024
Document type:
Article