SP-8356 inhibits acute lung injury by suppressing inflammatory cytokine production and immune cell infiltration.
Int Immunopharmacol
; 131: 111847, 2024 Apr 20.
Article
in En
| MEDLINE
| ID: mdl-38518593
ABSTRACT
This study investigated the anti-inflammatory and protective properties of SP-8356, a synthetic derivative of (1S)-(-)-verbenone, in a mouse model of LPS-induced acute lung injury (ALI). By targeting intracellular signaling pathways and inflammatory responses, SP-8356 demonstrated a potent ability to attenuate deleterious effects of proinflammatory stimuli. Specifically, SP-8356 effectively inhibited the activation of crucial signaling molecules such as NF-κB and Akt, and subsequently dampened the expression of inflammatory cytokines in various lung cellular components. Intervention with SP-8356 treatment also preserved the structural integrity of the epithelial and endothelial barriers. By reducing immune cell infiltration into inflamed lung tissue, SP-8356 exerted a broad protective effect against ALI. These findings position SP-8356 as a promising therapeutic candidate for pulmonary inflammatory diseases that cause ALI.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acute Lung Injury
/
Bicyclic Monoterpenes
Limits:
Animals
Language:
En
Journal:
Int Immunopharmacol
Year:
2024
Document type:
Article