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Smoking blunts sertraline response in depression: A prospective observational cohort study.
Mohan, Prafull; Chatterjee, Kaushik; Sinha, Sharmila; Saini, R K; Sharma, A K; Waikole, Suraj.
Affiliation
  • Mohan P; Classified Specialist (Pharmacology) & Commanding Officer, 421 Field Hospital, C/o 99 APO, India.
  • Chatterjee K; Professor & Head, Department of Psychiatry, Armed Forces Medical College, Pune, India.
  • Sinha S; Professor & Head, Department of Pharmacology, Armed Forces Medical College, Pune, India.
  • Saini RK; Senior Adviser (Psychiatry), Command Hospital (Eastern Command), Kolkata, India.
  • Sharma AK; Ex-Professor & Head, Department of Pharmacology, Armed Forces Medical College, Pune, India.
  • Waikole S; Resident, Department of Pharmacology, Armed Forces Medical College, Pune, India.
Med J Armed Forces India ; 80(2): 145-152, 2024.
Article in En | MEDLINE | ID: mdl-38525466
ABSTRACT

Background:

Smoking is common in patients of depression and is known to affect response to antidepressants. This study was undertaken to evaluate the effect of smoking on the antidepressant effect of sertraline.

Method:

Patients with depression were divided into smoker and nonsmoker cohorts and followed up for 8 weeks. Serum sertraline levels were estimated using the high-performance liquid chromatography system. Response to treatment was evaluated with the Hamilton Depression Rating Scale (HAM-D).

Results:

Serum sertraline levels did not differ between smokers and nonsmokers at 4 and 8 weeks. Nonsmokers responded better to sertraline than smokers after 8 weeks. Adverse drug reaction profile did not vary between the two groups and was not impacted by serum sertraline levels. Nonsmokers showed a greater fall in the HAM-D score than smokers.

Conclusion:

This study found depression among smokers to be less responsive to sertraline. This was not explained by serum sertraline levels. Treatment of depression in smokers with sertraline might require higher doses and duration, with more frequent reviews.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Med J Armed Forces India Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Med J Armed Forces India Year: 2024 Document type: Article