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Immunotherapy and Cancer: The Multi-Omics Perspective.
Donisi, Clelia; Pretta, Andrea; Pusceddu, Valeria; Ziranu, Pina; Lai, Eleonora; Puzzoni, Marco; Mariani, Stefano; Massa, Elena; Madeddu, Clelia; Scartozzi, Mario.
Affiliation
  • Donisi C; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Pretta A; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Pusceddu V; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Ziranu P; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Lai E; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Puzzoni M; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Mariani S; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Massa E; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Madeddu C; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
  • Scartozzi M; Medical Oncology Unit, Department of Medical Sciences and Public Health, "Azienda Ospedaliero Universitaria" of Cagliari, University of Cagliari, 09042 Cagliari, Italy.
Int J Mol Sci ; 25(6)2024 Mar 21.
Article in En | MEDLINE | ID: mdl-38542536
ABSTRACT
Immunotherapies have revolutionized cancer treatment approaches. Because not all patients respond positively to immune therapeutic agents, it represents a challenge for scientists who strive to understand the mechanisms behind such resistance. In-depth exploration of tumor biology, using novel technologies such as omics science, can help decode the role of the tumor immune microenvironment (TIME) in producing a response to the immune blockade strategies. It can also help to identify biomarkers for patient stratification and personalized treatment. This review aims to explore these new models and highlight their possible pivotal role in changing clinical practice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiomics / Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiomics / Neoplasms Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article