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Effect of vitamin E supplementation on bilirubin levels in infants with hyperbilirubinemia: a double-blind randomized clinical trial.
Cheraghi, Mojtaba; Nikouei, Maziar; Mansouri, Majid; Hemmatpour, Siros; Moradi, Yousef.
Affiliation
  • Cheraghi M; Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Nikouei M; Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Mansouri M; Department of Pediatric, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Hemmatpour S; Department of Pediatrics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Moradi Y; Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Clin Exp Pediatr ; 67(5): 249-256, 2024 May.
Article in En | MEDLINE | ID: mdl-38549357
ABSTRACT

BACKGROUND:

The effect of vitamin E supplementation on bilirubin levels in infants was previously explored, but the results were inconclusive.

PURPOSE:

To examine the effect of vitamin E supplementation on bilirubin levels in term infants in the neonatal intensive care unit (NICU).

METHODS:

This interventional double-blind randomized clinical trial was conducted in the Sanandaj Besat Hospital NICU. Enrolled newborns were between 37 and 42 weeks and 6 days of gestation and required phototherapy according to American Academy of Pediatrics clinical guidelines. A total of 138 infants were randomly assigned to vitamin E (n=68) or placebo (n=70) groups. In addition to phototherapy, the vitamin E group received 0.5 mL (5 IU) of supplemental vitamin E daily, whereas the placebo group received 0.5 mL of oral dextrose daily. STATA 17 was used for the data analysis.

RESULTS:

Changes in bilirubin levels at 24 hours postintervention did not differ significantly from baseline in either group. Vitamin E supplementation did not significantly reduce total bilirubin levels at 24 hours postintervention (mean difference [MD], -0.18; P=0.204; 95% confidence interval [CI], -1.39 to 1.02). However, the vitamin E group exhibited lower total bilirubin levels than the placebo group at 48 hours postintervention (MD, 0.18; P=0.365; 95% CI, -0.89 to 1.27) and 72 hours (MD, 0.36; P=0.356; 95% CI, -2.34 to 1.61), although the differences were not statistically significant. A subgroup analysis revealed that female infants experienced a greater reduction in total bilirubin levels than male infants.

CONCLUSION:

Infants administered vitamin E versus placebo demonstrated similar reductions in bilirubin levels and hospital stays. Although the average bilirubin changes did not differ significantly between groups, the vitamin E group showed a more noticeable reduction over time, indicating a positive effect of vitamin E supplementation on serum bilirubin reduction. Trial registration IRCT20220806055625N2 (registered December 26, 2022; http//irct.ir/trial/67135).
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Exp Pediatr Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Exp Pediatr Year: 2024 Document type: Article