A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques.
Curr Top Med Chem
; 24(8): 667-685, 2024.
Article
in En
| MEDLINE
| ID: mdl-38549525
ABSTRACT
Peptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This review summarizes successful cases of computer-aided design and screening of affinity peptide ligands in recent years and lists the computer programs and online servers used in the process. In particular, the characteristics of different design and screening methods are summarized and categorized to help researchers choose between different methods. In addition, experimentally validated sequences are listed, and their applications are described, providing directions for the future development and application of computational peptide screening and design.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Computer Simulation
Limits:
Humans
Language:
En
Journal:
Curr Top Med Chem
Year:
2024
Document type:
Article