Integrated proteogenomic and metabolomic characterization of papillary thyroid cancer with different recurrence risks.
Nat Commun
; 15(1): 3175, 2024 Apr 12.
Article
in En
| MEDLINE
| ID: mdl-38609408
ABSTRACT
Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains a core concern in the clinic. Molecular factors contributing to different recurrence risks (RRs) remain poorly defined. Here, we perform an integrative proteogenomic and metabolomic characterization of 102 Chinese PTC patients with different RRs. Genomic profiling reveals that mutations in MUC16 and TERT promoter as well as multiple gene fusions like NCOA4-RET are enriched by the high RR. Integrative multi-omics analyses further describe the multi-dimensional characteristics of PTC, especially in metabolism pathways, and delineate dominated molecular patterns of different RRs. Moreover, the PTC patients are clustered into four subtypes (CS1 low RR and BRAF-like; CS2 high RR and metabolism type, worst prognosis; CS3 high RR and immune type, better prognosis; CS4 high RR and BRAF-like) based on the omics data. Notably, the subtypes display significant differences considering BRAF and TERT promoter mutations, metabolism and immune pathway profiles, epithelial cell compositions, and various clinical factors (especially RRs and prognosis) as well as druggable targets. This study can provide insights into the complex molecular characteristics of PTC recurrences and help promote early diagnosis and precision treatment of recurrent PTC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Proteogenomics
Limits:
Humans
Language:
En
Journal:
Nat Commun
Year:
2024
Document type:
Article