Triglyceride-glucose index predicts postoperative delirium in elderly patients with type 2 diabetes mellitus: a retrospective cohort study.
Lipids Health Dis
; 23(1): 107, 2024 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-38622624
ABSTRACT
BACKGROUND:
Postoperative delirium (POD) is more prevalent among elderly patients with type 2 diabetes mellitus (T2DM). Insulin resistance (IR) can be assessed using the triglyceride-glucose (TyG) index, a novel biomarker. This study aims to investigate the predictive potential of the TyG index for POD in elderly patients with T2DM. MATERIALS ANDMETHODS:
Elderly patients (≥ 65) with T2DM who underwent non-neurosurgery and non-cardiac surgery were enrolled. Univariate and multivariate logistic regression analyses were conducted to assess the association between the TyG index and POD. Additionally, subgroup analyses were performed to compare the sex-specific differences in the predictive ability of the TyG index for POD.RESULTS:
A total of 4566 patients were included in this retrospective cohort. The receiver operating characteristic (ROC) curve analysis determined the optimal cut-off value for the TyG index to be 8.678. In the univariate model, a TyG index > 8.678 exhibited an odds ratio (OR) of 1.668 (95% CI 1.210-2.324, P = 0.002) for predicting POD. In the multivariate regression models, the ORs were 1.590 (95% CI 1.133-2.252, P < 0.008), 1.661 (95% CI 1.199-2.325, P < 0.003), and 1.603 (95% CI 1.137-2.283, P = 0.008) for different models. Subgroup analyses demonstrated that the predictive ability of the TyG index was more pronounced in females compared to males.CONCLUSION:
The TyG index shows promise as a novel biomarker for predicting the occurrence of POD in elderly surgical patients with T2DM.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Emergence Delirium
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Lipids Health Dis
Year:
2024
Document type:
Article