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Drug concentrations in hair and dried blood spots as PrEP adherence metrics during pregnancy and postpartum.
Wu, Linxuan; Kinuthia, John; Anderson, Peter L; Baeten, Jared M; Dettinger, Julia C; Gandhi, Monica; Gomez, Laurén; John-Stewart, Grace; Marwa, Mary M; Ngumbau, Nancy; Otieno, Felix; Omondi, Pascal; Odhiambo, Ben; Watoyi, Salphine; Pintye, Jillian.
Affiliation
  • Wu L; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Kinuthia J; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Anderson PL; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Baeten JM; Department of Research & Programs, Kenyatta National Hospital, Nairobi, Kenya.
  • Dettinger JC; Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
  • Gandhi M; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Gomez L; Department of Global Health, University of Washington, Seattle, WA, USA.
  • John-Stewart G; Department of Medicine, University of Washington, Seattle, USA.
  • Marwa MM; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Ngumbau N; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Otieno F; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Omondi P; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Odhiambo B; Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Watoyi S; Department of Global Health, University of Washington, Seattle, WA, USA.
  • Pintye J; Department of Pediatrics, School of Medicine, University of Washington, Seattle, USA.
J Infect Dis ; 2024 May 03.
Article in En | MEDLINE | ID: mdl-38700101
ABSTRACT
We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV pre-exposure prophylaxis (PrEP) during pregnancy and postpartum and compared hair levels with tenofovir-diphosphate (TFV-DP) levels in dried blood spots (DBS). Overall, 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster randomized trial. Having a partner known to be living with HIV was associated with higher hair TFV levels (p<0.001). Hair TFV concentrations were strongly correlated with DBS TFV-DP levels (r=0.76, p<0.001), indicating hair as promising cumulative adherence metric for perinatal PrEP assessment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis Year: 2024 Document type: Article
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Infect Dis Year: 2024 Document type: Article