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Cabotegravir and rilpivirine long acting injectables in a pregnant woman living with HIV.
van der Wekken-Pas, Lena; Weiss, Fabian; Simon-Zuber, Charlotte; Sebisch, Rena; Wiese, Carmen; van Leeuwen, Elisabeth; Burger, David; Colbers, Angela.
Affiliation
  • van der Wekken-Pas L; Radboud university medical center, department of pharmacy, Radboud Institute for Medical Innovations (RIMI), Nijmegen, the Netherlands.
  • Weiss F; Department of Obstetrics and Gynecology, LMU university hospital, LMU Munich, Germany.
  • Simon-Zuber C; Department of Obstetrics and Gynecology, LMU university hospital, LMU Munich, Germany.
  • Sebisch R; Department of Obstetrics and Gynecology, LMU university hospital, LMU Munich, Germany.
  • Wiese C; MVZ München am Goetheplatz, Munich, Germany.
  • van Leeuwen E; Amsterdam university medical center, department of gynecology, Amsterdam, the Netherlands.
  • Burger D; Radboud university medical center, department of pharmacy, Radboud Institute for Medical Innovations (RIMI), Nijmegen, the Netherlands.
  • Colbers A; Radboud university medical center, department of pharmacy, Radboud Institute for Medical Innovations (RIMI), Nijmegen, the Netherlands.
Clin Infect Dis ; 2024 May 03.
Article in En | MEDLINE | ID: mdl-38703388
ABSTRACT
This case report describes bimonthly LAI CAB/RPV prior to and throughout pregnancy. CAB concentration was comparable to non-pregnant individuals, RPV was 70-75% lower. No virologic failure orvertical transmission occurred. Despite placental transfer, no congenital malformations were noted. Bimonthly CAB/RPV LAI may not be suitable for pregnant women and monitoring of exposed infants is warranted.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Infect Dis / Clin. infect. dis / Clinical infectious diseases Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Infect Dis / Clin. infect. dis / Clinical infectious diseases Year: 2024 Document type: Article