Dual targeting total saponins of Pulsatilla of natural polymer crosslinked gel beads with multiple therapeutic effects for ulcerative colitis.
Eur J Pharm Biopharm
; 199: 114309, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38704102
ABSTRACT
Oral colon targeted drug delivery system (OCTDDS) is desirable for the treatment of ulcerative colitis (UC). In this study, we designed a partially oxidized sodium alginate-chitosan crosslinked microsphere for UC treatment. Dissipative particle dynamics (DPD) was used to study the formation and enzyme response of gel beads from a molecular perspective. The formed gel beads have a narrow particle size distribution, a compact structure, low cytotoxicity and great colon targeting in vitro and in vivo. Animal experiments demonstrated that gel beads promoted colonic epithelial barrier integrity, decreased the level of pro-inflammatory factors, accelerated the recovery of intestinal microbial homeostasis in UC rats and restored the intestinal metabolic disorders. In conclusion, our gel bead is a promising approach for the treatment of UC and significant for the researches on the pathogenesis and treatment mechanism of UC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saponins
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Colitis, Ulcerative
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Drug Delivery Systems
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Chitosan
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Alginates
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Gels
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Microspheres
Limits:
Animals
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Humans
/
Male
Language:
En
Journal:
Eur J Pharm Biopharm
/
Eur. j. pharm. biopharm
/
European journal of pharmaceutics and biopharmaceutics
Year:
2024
Document type:
Article