Impact of severe acute kidney injury on short-term mortality in urosepsis.
World J Urol
; 42(1): 301, 2024 May 08.
Article
in En
| MEDLINE
| ID: mdl-38717511
ABSTRACT
PURPOSE:
To evaluate the impact of severe acute kidney injury (AKI) on short-term mortality in patients with urosepsis.METHODS:
This prospective cohort study evaluated 207 patients with urosepsis. AKI was diagnosed in accordance with the Kidney Disease Improving Global Outcomes criteria, and severe AKI was defined as stage 2 or 3 AKI. Patients were divided into two groups patients who developed severe AKI (severe AKI group) and patients who did not (control group). The primary endpoint was all-cause mortality within 30 days. The secondary endpoints were 90-day mortality and in-hospital mortality. The exploratory outcomes were the risk factors for severe AKI development.RESULTS:
The median patient age was 79 years. Of the 207 patients, 56 (27%) developed severe AKI. The 30-day mortality rate in the severe AKI group was significantly higher than that in the control group (20% vs. 2.0%, respectively; P < 0.001). In the multivariable analysis, performance status and severe AKI were significantly associated with 30-day mortality. The in-hospital mortality and 90-day mortality rates in the severe AKI group were significantly higher than those in the control group (P < 0.001 and P < 0.001, respectively). In the multivariable analysis, age, urolithiasis-related sepsis, lactate values, and disseminated intravascular coagulation were significantly associated with severe AKI development.CONCLUSIONS:
Severe AKI was a common complication in patients with urosepsis and contributed to high short-term mortality rates.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urinary Tract Infections
/
Severity of Illness Index
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Hospital Mortality
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Sepsis
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Acute Kidney Injury
Limits:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
World J Urol
Year:
2024
Document type:
Article