Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial.
Nutrients
; 16(9)2024 Apr 28.
Article
in En
| MEDLINE
| ID: mdl-38732578
ABSTRACT
This study examined the effects of orange juice (OJ) supplemented with vitamin D3 (2000 IU) and probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG, 108 cfu/mL) on cardiometabolic risk factors in overweight and obese adults following a Westernized-type diet. Fifty-three high-risk individuals were randomly assigned to one of two groups. Over 8 weeks, one group consumed a vitamin D3 and probiotic-enriched OJ and the other regular OJ (control). Diets remained unchanged and were documented through food diaries. Measures of metabolic and inflammatory markers and blood pressure were measured at the start and end of the study. Post-intervention, the enriched OJ group showed the following significant metabolic improvements (without changes in triglycerides, inflammation, or central blood pressure) reduced fasting insulin, peripheral blood pressure, body weight (-1.4 kg 95% CI -2.4, -0.4), energy (-270 kcal 95% CI -553.2, -13.7), macronutrient (dietary fat -238 kcal 95% CI -11.9, -1.0; carbohydrates -155 kcal 95% CI -282.4, -27.3; sugars -16.1 g 95% CI -11.9, -1.0) intake, and better lipid profiles (total cholesterol -10.3 mg/dL 95% CI -21.4, 0.9; LDL-C -7 mg/dL 95% CI -13.5, -0.5). The enriched OJ led to weight loss, less energy/macronutrient consumption, improved lipid profiles, and increased insulin sensitivity after 8 weeks in those following a Westernized diet, thus indicating potential benefits for cardiometabolic risk. This study was a part of FunJuice-T2EDK-01922, which was funded by the EU Regional Development Fund and Greek National Resources.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
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Insulin Resistance
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Cholecalciferol
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Probiotics
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Citrus sinensis
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Diet, Western
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Fruit and Vegetable Juices
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Cardiometabolic Risk Factors
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Lipids
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Nutrients
Year:
2024
Document type:
Article