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Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application.
Shaqour, Bahaa; Natsheh, Hiba; Kittana, Naim; Jaradat, Nidal; Abualhasan, Murad; Eid, Ahmad M; Moqady, Ruaa; AbuHijleh, Aya; Abu Alsaleem, Saja; Ratrout, Shahd; De Wever, Lotte; Vervaet, Chris; Vanhoorne, Valérie.
Affiliation
  • Shaqour B; Mechanical and Mechatronics Engineering Department, Faculty of Engineering and Information Technology, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Natsheh H; Medical and Health Sciences Research Center, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Kittana N; Medical and Health Sciences Research Center, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Jaradat N; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Abualhasan M; Medical and Health Sciences Research Center, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Eid AM; Department of Biomedical Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Moqady R; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • AbuHijleh A; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Abu Alsaleem S; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Ratrout S; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • De Wever L; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Vervaet C; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
  • Vanhoorne V; Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
ACS Biomater Sci Eng ; 10(6): 3833-3841, 2024 06 10.
Article in En | MEDLINE | ID: mdl-38747490
ABSTRACT
This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalatepolyethylene glycol (HPMCPPEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCPPEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capsules / Ketoprofen / Emulsions / Precision Medicine / Drug Liberation / Printing, Three-Dimensional Limits: Humans Language: En Journal: ACS Biomater Sci Eng Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capsules / Ketoprofen / Emulsions / Precision Medicine / Drug Liberation / Printing, Three-Dimensional Limits: Humans Language: En Journal: ACS Biomater Sci Eng Year: 2024 Document type: Article