Influence of hydrogen bonds on state diagrams of cryoprotectant solutions.
Cryo Letters
; 45(4): 231-239, 2024.
Article
in En
| MEDLINE
| ID: mdl-38809787
ABSTRACT
BACKGROUND:
Transformation of state diagrams of cryoprotectant solutions under the influence of weak intramolecular interactions was considered. MATERIALS ANDMETHODS:
Phase states of aqueous glycerol and DMSO solutions within temperature range +25 to -150 degree С were studied using method of volumetric scanning tensodilatometry. Temperatures below which hydrogen bonds significantly affect crystallization-melting kinetics of such solutions were determined.RESULTS:
Principles for plotting of state diagram for binary solutions with weak intermolecular interaction of the components were set up. The study demonstrates that in such solutions formation of clusters based on ice microcrystals and cryoprotectant occurs. Based on the obtained results, state diagrams for glycerol and DMSO aqueous solutions were plotted. These diagrams include area of cluster phase existence and differ fundamentally from those describing eutectic crystallization.CONCLUSION:
Nanostructures occurring in cryoprotectant solutions during their cooling were analyzed. Difference between these structures and classical solid phase eutectics were demonstrated. Doi.org/10.54680/fr24410110712.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dimethyl Sulfoxide
/
Cryoprotective Agents
/
Crystallization
/
Glycerol
/
Hydrogen Bonding
Language:
En
Journal:
Cryo Letters
Year:
2024
Document type:
Article