Human sensorimotor resting state beta events and aperiodic activity show good test-retest reliability.
Clin Neurophysiol
; 163: 244-254, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38820994
ABSTRACT
OBJECTIVE:
Diseases affecting sensorimotor function impair physical independence. Reliable functional clinical biomarkers allowing early diagnosis or targeting treatment and rehabilitation could reduce this burden. Magnetoencephalography (MEG) non-invasively measures brain rhythms such as the somatomotor 'rolandic' rhythm which shows intermittent high-amplitude beta (14-30 Hz) 'events' that predict behavior across tasks and species and are altered by sensorimotor neurological diseases.METHODS:
We assessed test-retest stability, a prerequisite for biomarkers, of spontaneous sensorimotor aperiodic (1/f) signal and beta events in 50 healthy human controls across two MEG sessions using the intraclass correlation coefficient (ICC). Beta events were determined using an amplitude-thresholding approach on a narrow-band filtered amplitude envelope obtained using Morlet wavelet decomposition.RESULTS:
Resting sensorimotor characteristics showed good to excellent test-retest stability. Aperiodic component (ICC 0.77-0.88) and beta event amplitude (ICC 0.74-0.82) were very stable, whereas beta event duration was more variable (ICC 0.55-0.7). 2-3 minute recordings were sufficient to obtain stable results. Analysis automatization was successful in 86%.CONCLUSIONS:
Sensorimotor beta phenotype is a stable feature of an individual's resting brain activity even for short recordings easily measured in patients.SIGNIFICANCE:
Spontaneous sensorimotor beta phenotype has potential as a clinical biomarker of sensorimotor system integrity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beta Rhythm
/
Magnetoencephalography
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Clin Neurophysiol
Year:
2024
Document type:
Article