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Gut microbiome and symptoms in females with irritable bowel syndrome: a cross-sectional analysis.
Kamp, K J; Plantinga, A M; Cain, K C; Burr, R L; Tsai, C-S; Wu, Q; So, S Y; Badu, S; Savidge, T; Shulman, R J; Heitkemper, M M.
Affiliation
  • Kamp KJ; 16181University of Washington, School of Nursing, P.O. Box 357266, Seattle, WA 98195, USA.
  • Plantinga AM; Williams College, Williamstown, MA, USA.
  • Cain KC; 16181University of Washington, School of Nursing, P.O. Box 357266, Seattle, WA 98195, USA.
  • Burr RL; 16181University of Washington, School of Nursing, P.O. Box 357266, Seattle, WA 98195, USA.
  • Tsai CS; 16181University of Washington, School of Nursing, P.O. Box 357266, Seattle, WA 98195, USA.
  • Wu Q; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • So SY; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Badu S; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Savidge T; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Shulman RJ; Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Heitkemper MM; 16181University of Washington, School of Nursing, P.O. Box 357266, Seattle, WA 98195, USA.
Benef Microbes ; 15(3): 259-273, 2024 May 28.
Article in En | MEDLINE | ID: mdl-38821492
ABSTRACT
Irritable bowel syndrome (IBS), a disorder of gut-brain interaction, is associated with abdominal pain and stool frequency/character alterations that are linked to changes in microbiome composition. We tested whether taxa differentially abundant between females with IBS vs healthy control females (HC) are associated with daily gastrointestinal and psychological symptom severity. Participants (age 18-50 year) completed a 3-day food record and collected a stool sample during the follicular phase. They also completed a 28-day diary rating symptom intensity; analysis focused on the three days after the stool sample collection. 16S rRNA gene sequencing was used for bacterial identification. Taxon abundance was compared between IBS and HC using zero-inflated quantile analysis (ZINQ). We found that females with IBS (n = 67) had greater Bacteroides abundance (q = 0.003) and lower odds of Bifidobacterium presence (q = 0.036) compared to HC (n = 46) after adjusting for age, race, body mass index, fibre intake, and hormonal contraception use. Intestimonas, Oscillibacter, and Phascolarctobacterium were more often present and Christensenellaceae R-7 group, Collinsella, Coprococcus 2, Moryella, Prevotella 9, Ruminococcaceae UCG-002, Ruminococcaceae UCG-005, and Ruminococcaceae UCG-014 were less commonly present in IBS compared to HC. Despite multiple taxon differences in IBS vs HC, we found no significant associations between taxon presence or abundance and average daily symptom severity within the IBS group. This may indicate the need to account for interactions between microbiome, dietary intake, metabolites, and host factors.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / RNA, Ribosomal, 16S / Irritable Bowel Syndrome / Feces / Gastrointestinal Microbiome Limits: Adolescent / Adult / Female / Humans / Middle aged Language: En Journal: Benef Microbes Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / RNA, Ribosomal, 16S / Irritable Bowel Syndrome / Feces / Gastrointestinal Microbiome Limits: Adolescent / Adult / Female / Humans / Middle aged Language: En Journal: Benef Microbes Year: 2024 Document type: Article