Genetic association mapping leveraging Gaussian processes.
J Hum Genet
; 69(10): 505-510, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-38834722
ABSTRACT
Gaussian processes (GPs) are a powerful and useful approach for modelling nonlinear phenomena in various scientific fields, including genomics and genetics. This review focuses on the application of GPs in genetic association mapping. The aim is to identify genetic variants that alter gene regulation along continuous cellular states at the molecular level, as well as disease susceptibility over time and space at the population level. The challenges and opportunities in this field are also addressed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Genetic
Limits:
Humans
Language:
En
Journal:
J Hum Genet
Year:
2024
Document type:
Article