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Effective cultivation conditions and safety evaluation of filamentous cyanobacteria producing phycocyanins with antiglycation activities.
Aoki, Jinichi; Ozaki, Takato; Koshikawa, Runa; Sasaki, Daisaku; Kitajima, Katsuyoshi; Yoshida, Yuta; Nakajima, Hiromi; Asayama, Munehiko.
Affiliation
  • Aoki J; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
  • Ozaki T; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan.
  • Koshikawa R; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan.
  • Sasaki D; BioX Chemical Industries Co. Ltd., Hiroshima 733-0844, Japan.
  • Kitajima K; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
  • Yoshida Y; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan.
  • Nakajima H; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan.
  • Asayama M; College of Agriculture, Ibaraki University, Ibaraki 300-0393, Japan; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan. Electronic address: munehiko.asayama.777@vc.ibaraki.ac.jp.
J Biotechnol ; 391: 64-71, 2024 Aug 10.
Article in En | MEDLINE | ID: mdl-38844247
ABSTRACT
We investigated suitable culture conditions for the production of the blue pigment phycocyanin (PC) from the unique filamentous cyanobacteria Pseudanabaena sp. ABRG5-3 and Limnothrix sp. SK1-2-1. White, green, or red LED irradiation at 30 µmol photons/m2/s was effective for phycocyanin production when compared with Arthrospira platensis (Spirulina) sp. NIES-39, which is generally grown under high light irradiation. To investigate the safety of the cyanobacteria, ABRG5-3 cells were subjected to Ames (reverse mutation) tests and single oral-dose rat studies, which revealed non-mutagenic and non-toxic properties. When three purified phycocyanins (abPC, skPC, and spPC) were subjected to agarose gel electrophoresis, they showed different mobility, indicating that each phycocyanin has unique properties. abPC exhibited strong antiglycation activities as novel function.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phycocyanin / Cyanobacteria Limits: Animals Language: En Journal: J Biotechnol / J. biotechnol / Journal of biotechnology Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phycocyanin / Cyanobacteria Limits: Animals Language: En Journal: J Biotechnol / J. biotechnol / Journal of biotechnology Year: 2024 Document type: Article