Your browser doesn't support javascript.
loading
The picky mTORC1 in metabolic enzyme degradation.
Chun, Yujin; Fruman, David A; Lee, Gina.
Affiliation
  • Chun Y; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, USA.
  • Fruman DA; Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA.
  • Lee G; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA. Electronic address: ginalee@uci.edu.
Mol Cell ; 84(11): 2011-2013, 2024 Jun 06.
Article in En | MEDLINE | ID: mdl-38848689
ABSTRACT
In this issue of Molecular Cell, Yi et al.1 demonstrate that reduced mTORC1 activity induces the CTLH E3 ligase-dependent degradation of HMGCS1, an enzyme in the mevalonate pathway, thus revealing a unique connection between mTORC1 signaling and the degradation of a specific metabolic enzyme via the ubiquitin-proteasome system.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Proteasome Endopeptidase Complex / Mechanistic Target of Rapamycin Complex 1 Limits: Animals / Humans Language: En Journal: Mol Cell Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Proteasome Endopeptidase Complex / Mechanistic Target of Rapamycin Complex 1 Limits: Animals / Humans Language: En Journal: Mol Cell Year: 2024 Document type: Article