Your browser doesn't support javascript.
loading
The role of mitochondrial genes in ischemia-reperfusion injury: A systematic review of experimental studies.
Chen, Zeyu; Rayner, Daniel; Morton, Robert; Banfield, Laura; Paré, Guillaume; Chong, Michael.
Affiliation
  • Chen Z; David Braley Cardiac Research Institute, Thrombosis & Atherosclerosis Research Institute, Population Health Research Institute, Canada; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
  • Rayner D; David Braley Cardiac Research Institute, Thrombosis & Atherosclerosis Research Institute, Population Health Research Institute, Canada; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
  • Morton R; Novo Nordisk Foundation, Copenhagen, Denmark.
  • Banfield L; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
  • Paré G; David Braley Cardiac Research Institute, Thrombosis & Atherosclerosis Research Institute, Population Health Research Institute, Canada; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
  • Chong M; David Braley Cardiac Research Institute, Thrombosis & Atherosclerosis Research Institute, Population Health Research Institute, Canada; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. Electronic address: michael.chong@crlb-gmel.ca.
Mitochondrion ; 78: 101908, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38848983
ABSTRACT
Mitochondrial dysfunction contributes to pathological conditions like ischemia-reperfusion (IR) injury. To address the lack of effective therapeutic interventions for IR injury and potential knowledge gaps in the current literature, we systematically reviewed 3800 experimental studies across 5 databases and identified 20 mitochondrial genes impacting IR injury in various organs. Notably, CyPD, Nrf2, and GPX4 are well-studied genes consistently influencing IR injury outcomes. Emerging genes like ALDH2, BNIP3, and OPA1 are supported by human genetic evidence, thereby warranting further investigation. Findings of this review can inform future research directions and inspire therapeutic advancements.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury Limits: Animals / Humans Language: En Journal: Mitochondrion Year: 2024 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury Limits: Animals / Humans Language: En Journal: Mitochondrion Year: 2024 Document type: Article