Three new antinociceptive diterpenoids from the fruits of Rhododendron molle.
J Asian Nat Prod Res
; : 1-9, 2024 Jun 09.
Article
in En
| MEDLINE
| ID: mdl-38853517
ABSTRACT
Investigation of the fruits of Rhododendron molle G. Don led to the isolation of three new grayanane-type diterpenoids, rhodomolleins LIV-LVI (1-3). The structures and absolute configurations of new compounds were fully elucidated by spectroscopic analysis and single-crystal X-ray diffraction, including HRESIMS, 1 D and 2 D NMR data. Compounds 1-3 were evaluated for analgesic activities utilizing an acetic acid-induced writhing test in mice. Compound 1 showed a significant antinociceptive effect with writhe inhibition rates of 72.9% and 100% at doses of 6 mg/kg and 20 mg/kg in mice, respectively. The binding mode of 1 to N-ethylmaleimide-sensitive factor (NSF, PDB 6IP2) was explored by molecular docking, indicating the presence of hydrogen bond interactions which account for its analgesic activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Asian Nat Prod Res
Year:
2024
Document type:
Article