Pyridine-borane complex-catalysed thioesterification: the direct conversion of carboxylic acids to thioesters.
Chem Commun (Camb)
; 60(52): 6671-6674, 2024 Jun 25.
Article
in En
| MEDLINE
| ID: mdl-38860640
ABSTRACT
Thioesters are a common class of biologically active fragments and synthetically useful building blocks. An attractive synthetic approach would be to use simple and bench-stable carboxylic acids as a coupling partner. Herein, we present a 4-bromo pyridine-borane complex as a catalyst for the direct coupling of carboxylic acids with thiols. A wide range of thioesters with good functional group compatibility could be prepared via this metal-free approach. The merit of this strategy is exemplified by the modification of carboxylic acid-containing drugs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Year:
2024
Document type:
Article