Comparing the diagnostic efficacy of optical coherence tomography and frozen section for margin assessment in breast-conserving surgery: a meta-analysis.
J Clin Pathol
; 77(8): 517-527, 2024 Jul 18.
Article
in En
| MEDLINE
| ID: mdl-38862215
ABSTRACT
AIMS:
This meta-analysis assessed the relative diagnostic accuracy of optical coherence tomography (OCT) versus frozen section (FS) in evaluating surgical margins during breast-conserving procedures.METHODS:
PubMed and Embase were searched for relevant studies published up to October 2023. The inclusion criteria encompassed studies evaluating the diagnostic accuracy of OCT or FS in patients undergoing breast-conserving surgery. Sensitivity and specificity were analysed using the DerSimonian and Laird method and subsequently transformed through the Freeman-Tukey double inverse sine method.RESULTS:
The meta-analysis encompassed 36 articles, comprising 16 studies on OCT and 20 on FS, involving 10 289 specimens from 8058 patients. The overall sensitivity of OCT was 0.93 (95% CI 0.90 to 0.96), surpassing that of FS, which was 0.82 (95% CI 0.71 to 0.92), indicating a significantly higher sensitivity for OCT (p=0.04). Conversely, the overall specificity of OCT was 0.89 (95% CI 0.83 to 0.94), while FS exhibited a higher specificity at 0.97 (95% CI 0.95 to 0.99), suggesting a superior specificity for FS (pï¼0.01).CONCLUSIONS:
Our meta-analysis reveals that OCT offers superior sensitivity but inferior specificity compared with FS in assessing surgical margins in breast-conserving surgery patients. Further larger well-designed prospective studies are needed, especially those employing a head-to-head comparison design. PROSPERO REGISTRATION NUMBER CRD42023483751.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Mastectomy, Segmental
/
Tomography, Optical Coherence
/
Margins of Excision
/
Frozen Sections
Limits:
Female
/
Humans
Language:
En
Journal:
J Clin Pathol
/
J. clin. pathol
/
Journal of clinical pathology
Year:
2024
Document type:
Article