Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer's Disease.
J Alzheimers Dis
; 100(1): 333-343, 2024.
Article
in En
| MEDLINE
| ID: mdl-38875037
ABSTRACT
Background:
Amnestic syndrome of the hippocampal type (ASHT) in Memory Clinics is a presentation common to Alzheimer's disease (AD). However, ASHT can be found in other neurodegenerative disorders.Objective:
To compare brain morphometry including hippocampal volumes between amnestic older adults with and without AD pathology and investigate their relationship with memory performance and cerebrospinal fluid (CSF) biomarkers.Methods:
Brain morphometry of 92 consecutive patients (72.5±6.8 years old; 39% female) with Free and Cued Selective Recall Reminding Test (FCSRT) total recallâ<â40/48 was assessed with an automated algorithm and compared between AD and non-AD patients, as defined by CSF biomarkers.Results:
AD and non-AD patients presented comparable brain morphology. Total recall was associated to hippocampal volume irrespectively from AD pathology.Conclusions:
Brain morphometry, including hippocampal volumes, is similar between AD and non-AD older adults with ASHT evaluated in a Memory Clinic, underlying the importance of using molecular biomarkers for the diagnosis of AD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Magnetic Resonance Imaging
/
Alzheimer Disease
/
Amnesia
/
Hippocampus
Limits:
Aged
/
Aged80
/
Female
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Humans
/
Male
Language:
En
Journal:
J Alzheimers Dis
Year:
2024
Document type:
Article