Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis.
Nutrients
; 16(11)2024 May 31.
Article
in En
| MEDLINE
| ID: mdl-38892659
ABSTRACT
CONTEXT Short-chain fatty acids (SCFAs) have been reported to be associated with the pathogenesis of irritable bowel syndrome (IBS), but the results are conflicting. OBJECTIVE:
Here, a systematic review of case-control studies detecting fecal SCFAs in IBS patients compared with healthy controls (HCs) and self-controlled studies or randomized controlled trials (RCTs) investigating fecal SCFA alterations after interventions were identified from several databases. DATA SOURCES A systematic search of databases (PubMed, Web of Science, and Embase) identified 21 studies published before 24 February 2023. Data extractions Three independent reviewers completed the relevant data extraction. DATAANALYSIS:
It was found that the fecal propionate concentration in IBS patients was significantly higher than that in HCs, while the acetate proportion was significantly lower. Low-FODMAP diets significantly reduced the fecal propionate concentration in the IBS patients while fecal microbiota transplantation and probiotic administration did not significantly change the fecal propionate concentration or acetate proportion.CONCLUSIONS:
The results suggested that the fecal propionate concentration and acetate proportion could be used as biomarkers for IBS diagnosis. A low-FODMAP diet intervention could potentially serve as a treatment for IBS while FMT and probiotic administration need more robust trials.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Irritable Bowel Syndrome
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Fatty Acids, Volatile
/
Feces
Limits:
Adult
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Female
/
Humans
/
Male
Language:
En
Journal:
Nutrients
Year:
2024
Document type:
Article