Impact of frailty on perioperative outcomes following percutaneous nephrolithotomy in older persons: evidence from the US Nationwide Inpatient Sample.
Urolithiasis
; 52(1): 95, 2024 Jun 19.
Article
in En
| MEDLINE
| ID: mdl-38896137
ABSTRACT
To evaluate the impact of frailty on perioperative outcomes of older patients undergoing PCNL, utilizing the US Nationwide Inpatient Sample (NIS) database. Data of hospitalized patients ≥ 60 years who received PCNL were extracted from the 2010 to 2020 NIS database, and included demographics, clinical, and hospital-related information. Patients were assigned to low (< 5), medium (5-15), and high frailty risk (> 15) groups based on the hospital frailty risk score (HFRS). Associations between frailty risk and perioperative outcomes including total hospital cost were determined using population-weighted linear and logistic regression analyses. Data of 30,829 hospitalized patients were analyzed (mean age 72.5 years; 55% male; 78% white). Multivariable analyses revealed that compared to low frailty risk, increased frailty risk was significantly associated with elevated in-hospital mortality (adjusted odds ratio (aOR) = 10.70, 95% confidence interval (CI) 6.38-18.62), higher incidence of unfavorable discharge (aOR = 5.09, 95% CI 4.43-5.86), prolonged hospital length of stay (LOS; aOR = 7.67, 95% CI 6.38-9.22), increased transfusion risk (aOR = 8.05, 95% CI 6.55-9.90), increased total hospital costs (adjusted Beta = 37.61, 95% CI 36.39-38.83), and greater risk of complications (aOR = 8.52, 95% CI 7.69-9.45). Frailty is a significant prognostic indicator of adverse perioperative outcomes in older patients undergoing PCNL, underscoring importance of recognizing and managing frailty in older patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Hospital Mortality
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Frailty
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Nephrolithotomy, Percutaneous
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Length of Stay
Limits:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Urolithiasis
Year:
2024
Document type:
Article