The role of gut microbiota in anorexia induced by T-2 toxin.
Ecotoxicol Environ Saf
; 281: 116612, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38896898
ABSTRACT
T-2 toxin is one of trichothecene mycotoxins, which can impair appetite and decrease food intake. However, the specific mechanisms for T-2 toxin-induced anorexia are not fully clarified. Multiple research results had shown that gut microbiota have a significant effect on appetite regulation. Hence, this study purposed to explore the potential interactions of the gut microbiota and appetite regulate factors in anorexia induced by T-2 toxin. The study divided the mice into control group (CG, 0â¯mg/kg BW T-2 toxin) and T-2 toxin-treated group (TG, 1â¯mg/kg BW T-2 toxin), which oral gavage for 4 weeks, to construct a subacute T-2 toxin poisoning mouse model. This data proved that T-2 toxin was able to induce an anorexia in mice by increased the contents of gastrointestinal hormones (CCK, GIP, GLP-1 and PYY), neurotransmitters (5-HT and SP), as well as pro-inflammatory cytokines (IL-1ß, IL-6 and TNF-α) in serum of mice. T-2 toxin disturbed the composition of gut microbiota, especially, Faecalibaculum and Allobaculum, which was positively correlated with CCK, GLP-1, 5-HT, IL-1ß, IL-6 and TNF-α, which played a certain role in regulating host appetite. In conclusion, gut microbiota changes (especially an increase in the abundance of Faecalibaculum and Allobaculum) promote the upregulation of gastrointestinal hormones, neurotransmitters, and pro-inflammatory cytokines, which may be a potential mechanism of T-2 toxin-induced anorexia.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-2 Toxin
/
Anorexia
/
Gastrointestinal Microbiome
Limits:
Animals
Language:
En
Journal:
Ecotoxicol Environ Saf
Year:
2024
Document type:
Article