Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report.
BMC Nephrol
; 25(1): 204, 2024 Jun 21.
Article
in En
| MEDLINE
| ID: mdl-38907217
ABSTRACT
BACKGROUND:
The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare. However, delayed recognition or misdiagnosis leads to delayed treatment, resulting in worse renal and patient outcomes. CASE PRESENTATION We present 3 patients with rapidly progressive glomerulonephritis (RPGN), anti-GBM and serum-positive M-type phospholipase A2 receptor (anti-PLA2R) antibody. Renal biopsies revealed PLA2R-associated membranous nephropathy with anti-GBM glomerulonephritis. We analyzed the clinical and pathological characteristics and discussed that the correct diagnosis of membranous nephropathy with anti-GBM should rely on a combination of renal biopsy findings and serological testing. Despite aggressive treatment, one patient received maintenance hemodialysis, one patient progressed to CKD 3 stage, and the other patient died of cerebral infarction.CONCLUSION:
The simultaneous occurrence of membranous nephropathy and anti-GBM disease is extremely rare. The correct diagnosis of membranous nephropathy with anti-GBM relies on a combination of renal biopsy findings and serological testing. Early diagnosis is needed to improve the renal dysfunction.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glomerulonephritis, Membranous
/
Anti-Glomerular Basement Membrane Disease
/
Receptors, Phospholipase A2
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
BMC Nephrol
Year:
2024
Document type:
Article